The Helio Sequence is an American alternative rock duo from Beaverton, Oregon, signed to Sub Pop. The band was formed in 1999 and consists of Brandon Summers on vocals and guitars and Benjamin Weikel on drums and keyboards. The band has released three albums on Sub Pop, two on the Portland-based label Cavity Search and a self-released EP. Their fifth album, entitled Negotiations, was released on September 11, 2012, on Sub Pop.

The Helio Sequence toured with the British band Keane through the U.S.A. in 2009, and in June 2010, they were Keane's support act in several gigs through Great Britain during the British band's Night Train Tour. In September 2013, they began a U.S.A. tour co-headlining with Menomena.