SL2 may refer to:
- SL2 (musical group), British DJ and dance rave act
- Leicaflex SL2, a Leica mechanical reflex camera favoured by press photographers
- SL2, dirigeable airship List of Schütte-Lanz airships#SL2, used for bombing Warsaw in WWI
- SL2, car in the Saturn S-Series
- SL2 flavivirus, clones in cancer research
- SL2 RNA, a non-coding RNA involved in trans splicing in lower eukaryotes
- SL postcode area, the Slough postal region covering Farnham
- the mathematical structure SL2(F) special linear group
- special Lie algebra Special linear Lie algebra
- the NASA SL-2 space mission Skylab 2
- Situational Leadership II
