Melissa Lou Etheridge (born May 29, 1961) is an American rock singer-songwriter, guitarist, and activist. Her self-titled debut album was released in 1988 and became an underground hit. The album peaked at #22 on the Billboard 200, and its lead single, "Bring Me Some Water", garnered Etheridge her first Grammy nomination for Best Female Rock Vocal Performance. In 1993, Etheridge won her first Grammy award for her single "Ain't It Heavy" from her third album, Never Enough. Later that year, she released what would become her breakthrough album, Yes I Am. The album featured the mainstream rock hits "I'm the Only One" (#8) and "Come to My Window" (#25), the latter which scored Etheridge her second Grammy award. Yes I Am peaked at #15 on the Billboard 200, and spent 138 weeks on the chart, earning a RIAA certification of 6x Platinum, her largest to date.

In October 2004, Etheridge was diagnosed with breast cancer, and underwent surgery and chemotherapy. At the 2005 Grammy Awards, she made a return to the stage and, although bald from chemotherapy, performed a tribute to Janis Joplin with the song "Piece of My Heart". Etheridge's performance was widely lauded, with India.Arie writing "I Am Not My Hair" about Etheridge. Later that year, Etheridge released her first compilation album, Greatest Hits: The Road Less Traveled. The album was a huge success, peaking at #14 on the Billboard 200, and going Gold almost immediately. Her latest release is 4th Street Feeling.