H.U.M.A.N.W.I.N.E. (often printed as HUMANWINE) is a band based out of Boston, Massachusetts, United States. Their name is an acronym of the phrase, "Humans Underground Making Anagrams Nightly While Imperialistic Not-Mes Enslave". This is a reference to the subtly-coded lyrics that comprise most of their songs. Founded in 2002 by Holly Brewer and Mat McNiss, this band features a rotating lineup of supporting musicians.

HUMANWINE has received various nominations and awards. They have been featured in articles in many sources including the Boston Phoenix, the Boston Herald, The Pitch, The Dallas Morning News, and the Worcester Telegram & Gazette, as well as being featured on the cover of Northeast Performer Magazine.