Rose Polenzani (born March 7, 1975 in Waukesha, Wisconsin) is an independent folk musician. She was raised in the Chicago area and attended Knox College before leaving to pursue a singing career. She is currently living in Boston, Massachusetts. She plays guitar and, less frequently, piano. Her lyrics often blend obscure images and emotions.

Polenzani has performed in Lilith Fair in 1998, and the Sundance Film Festival in 1999. She has opened for the Indigo Girls, David Gray, Vic Chesnutt, Patty Griffin, Joan Baez, Jonatha Brooke, Kristin Hersh and Shawn Colvin. She has been reviewed positively in the Utne Reader, BUST Magazine, and the Boston Globe.