Don Byron (born November 8, 1958) is an American composer and multi-instrumentalist. He primarily plays clarinet, but has also used bass clarinet and saxophones.

Though rooted in jazz, Byron's music is stylistically eclectic. He has worked in many different musical genres, ranging from klezmer music and German lieder, to Raymond Scott's "cartoon-jazz," hard rock/metal, and rap. Most of Byron's albums have been conceptual, devoted to works of a particular musician and/or style of music.