Jean-Christophe Spinosi (born 2 September 1964) is a French conductor and violinist, the founder of Quatuor Matheus (1991), a group that later grew into Ensemble Matheus. He is especially well known for his interpretation of the instrumental and vocal music of the Baroque, most notably the operas of Vivaldi. Recently he has also conducted successful performances of Mozart and Rossini.

Spinosi has conducted many vocal works featuring singers such as Verónica Cangemi, Sara Mingardo, Jennifer Larmore, Sandrine Piau, Simone Kermes, Marie-Nicole Lemieux, Nathalie Stutzmann, Marjana Mijanovic, Lorenzo Regazzo, Philippe Jaroussky, and Matthias Goerne.