The Orchestre Philharmonique de Strasbourg (Strasbourg Philharmonic Orchestra) is a French orchestra based in Strasbourg. It is one of the two permanent orchestras of the Opéra national du Rhin. The orchestra's current principal venue is the Palais de la musique et des congrès 'Pierre Pflimlin ' (PMC Pierre-Pflimlin, or PMC).

The orchestra was founded in 1855. Between 1871 and 1918, and 1940 and 1944, the orchestra had been a German one, resulting from conflicts between France and Germany over the Alsace region. In 1997, the orchestra acquired the official title of Orchestre philharmonique de Strasbourg – orchestre national. The orchestra currently holds 110 permanent musicians. The French composer Jean-Louis Agobet was composer-in-residence from 2001 to 2004.