Francesco De Masi (January 11, 1930 – November 6, 2005) was an Italian conductor and film score composer.

He studied composition at the San Pietro a Maiella Conservatory in Naples, under the guidance of Achille Longo, his uncle. De Masi became interested in film music when Longo was asked to compose a soundtrack for a film, and he asked De Masi to be his assistant. De Masi's filmography includes scores for over 200 films and TV series, ranging from spaghetti westerns and sword and sandal epics to gialli and horror films, such as Lucio Fulci's Lo squartatore di New York (The New York Ripper). De Masi died of cancer at the age of 75.