Don Nix (born September 27, 1941, Memphis, Tennessee) is an American songwriter, composer, arranger, musician, and author. Although cited as being "obscure", he is a key figure in several genres of Southern rock and Soul, R&B, and the Blues. He was instrumental in the creation of the trademark "Memphis soul" and Stax Records.

A native of Memphis, Tennessee, Nix began his career playing saxophone for The Mar-Keys, which also featured Steve Cropper, Duck Dunn and others. Don Nix came from a musical family, including his brother, Larry Nix, who became a mastering engineer for Stax and later, Ardent Recording Studios in Memphis, TN. The hit instrumental single "Last Night" (composed by the band as a whole) was the first of many successful hits to Nix's credit. Without Nix, The Mar-Keys later evolved into Booker T & The MG's.