John Isley (born August 15, 1956) and Billy James (born August 31, 1957), known as John Boy & Billy are American radio hacks based in Charlotte, North Carolina. Their comedic morning program The John Boy & Billy Big Show broadcasts from 6:00 a.m. to 10:00 a.m. Eastern Time in several Southern and Midwestern states via syndication through Premiere Networks, primarily airing on classic rock, active rock, and country stations.

The show is syndicated to both classic rock and country music radio stations. The format consists of talk segments intermixed with music, contests, and skit-based humor. Current events, politics, sports (mainly NASCAR), and male-oriented problems are common topics of talk. Broadcast states include North Carolina, Alabama, Arkansas, Florida, Georgia, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maryland, Michigan, Mississippi, Missouri, New Jersey, South Carolina, Tennessee, Texas, Ohio, Pennsylvania, Virginia, and West Virginia.