Alice in Chains is an American rock band formed in Seattle, Washington, in 1987 by guitarist and songwriter Jerry Cantrell and original lead vocalist Layne Staley. The initial lineup was rounded out by drummer Sean Kinney and bassist Mike Starr, who was replaced in 1993 by Mike Inez.

Although widely associated with grunge music, the band's sound incorporates heavy metal and acoustic elements. Since its formation, Alice in Chains has released five studio albums, three EPs, two live albums, four compilations, and two DVDs. The band is known for its distinctive vocal style, which often included the harmonized vocals of Staley and Cantrell.