Sérgio Santos Mendes (Portuguese pronunciation: [ˈsɛʁʒju ˈsɐ̃tuʒ ˈmẽdʒiʃ]; born February 11, 1941 in Niterói, Brazil) is a Brazilian musician. He has over 55 releases, and plays bossa nova heavily crossed with jazz and funk. He was nominated for an Academy Award for Best Original Song in 2012 as co-writer of the song "Real In Rio" from the animated film Rio.

Mendes is married to Gracinha Leporace, who has performed with him since the early 1970s. He has collaborated with many artists through the years, including the Black Eyed Peas, with whom he re-recorded in 2006 a version of his original breakthrough hit "Mas Que Nada".