Morphine was an American alternative rock group formed by Mark Sandman, Dana Colley and Jerome Deupree in Cambridge, Massachusetts in 1989. After five successful albums and extensive touring, they disbanded in 1999 after frontman Sandman died of a heart attack.

Morphine combined blues and jazz elements with more traditional rock arrangements, giving the band an unusual sound. Sandman sang distinctively in a "deep, laid-back croon", and his songwriting featured a prominent beat influence. The band themselves coined the label "low rock" to describe their music, which involved "a minimalist, low-end sound that could have easily become a gimmick: a 'power trio' not built around the sound of an electric guitar. Instead, with sly intelligence, Morphine expanded its offbeat vocabulary on each album."