The Orquesta Sinfónica Simón Bolívar (Simón Bolívar Symphony Orchestra) is a Venezuelan orchestra. Named after the Venezuelan national hero Simón Bolívar, it is the apex of the nation's system of youth orchestras, although by 2011, it was no longer officially a youth orchestra because the average age of the players had risen too high. The country's national youth orchestra is now the Teresa Carreño Youth Orchestra.

The economist José Antonio Abreu established the Orquesta Sinfónica Simón Bolívar on 12 February 1975. Gustavo Dudamel has been the orchestra's artistic director since 1999. The orchestra has worked with many famous conductors including Claudio Abbado and Simon Rattle.