Johnny Hamp's Kentucky Serenaders was an US jazz and dance band, active from the late 1910s through the 1920s. The group was known simply as The Serenaders until Johnny Hamp became the band leader. Johnny Hamp was born in Lancaster, Pennsylvania and should not be confused with British television producer Johnnie Hamp. According to some sources, he became the leader by chance when the band was performing at the Hershey Ballroom in Hershey, Pennsylvania. The band leader at the time had an argument with the players and walked out. Hamp, with no experience as a band leader or conductor, volunteered to lead them for the rest of the evening and they accepted. After the performance, the band asked him to stay on as leader. The "Kentucky" in the name appears to be related to the band's use of "My Old Kentucky Home" as a theme song, rather than any connection to the U.S. state of Kentucky.

The group toured in the eastern United States and toured England in 1930. In 1931, the group was renamed Johnny Hamp and His Orchestra.