Giant Sand (also currently recording as Giant Giant Sand) is an American rock band, based in Tucson, Arizona, United States. The name is shortened from the original 'Giant Sandworms', a reference to the creatures in the Dune books. Overseen by singer-songwriter Howe Gelb, its membership has shifted over the years — at times with each album.

Members have included keyboardist Chris Cacavas (of Green on Red), bassist Paula Jean Brown (who was briefly a member of The Go-Go's and was married to Gelb at the time), Mark Walton (of The Dream Syndicate and Continental Drifters), drummer Tom Larkins (later to become a Jonathan Richman sideman). and Iain Shedden, drummer with Australian band The Saints. For a long while the band's rhythm section consisted of John Convertino and Joey Burns (of Calexico fame). In the early 2000s Howe Gelb reinvented the band again - this time with players from Denmark.