The Mound City Blue Blowers were an American novelty jazz ensemble, formed in St. Louis, Missouri and given its nickname. It was co-founded by Red McKenzie and Jack Bland and performed during in the 1920s and 1930s.

First assembled in 1923, the group's original members were Red McKenzie playing comb and tissue paper, Dick Slevin on kazoo, and Jack Bland on banjo. The band also included, in lieu of a drum kit, a traveler's suitcase played with foot and whisk brooms. Their debut recording, the 1924 release "Arkansas Blues" b/w "Blue Blues", was a hit in the Midwest. They recorded twelve tunes in 1924 and 1925; Frankie Trumbauer and Eddie Lang played on some of the tracks.