Los Straitjackets is an American instrumental rock band that formed in Nashville, Tennessee in 1988. Originally comprising guitarists Danny Amis (formerly of Raybeats) and Eddie Angel and drummer L. J. "Jimmy" Lester under the name The Straitjackets, the band split up soon after forming and reunited as Los Straitjackets in 1994 with the addition of bassist E. Scott Esbeck. Esbeck left the band in 1998 and was replaced by Pete Curry. The current lineup also features Greg Townson on guitar and Chris Sprague on drums.

The band has released thirteen studio albums, four collaboration albums and three live albums.