Daphne Rubin-Vega (born November 18, 1969 in Panama City, Panama) is a dancer, singer-songwriter, and actress. She is best known for originating the role of Mimi Marquez in the Broadway musical Rent, and the role of Lucy, in the Off-Broadway play Jack Goes Boating.

In 2012, Daphne also appeared as Bombshell publicist Agnes in the second season of the NBC TV series Smash.