Eric Kloss (born April 3, 1949, Greenville, Pennsylvania) is an American jazz saxophonist.

Blind since birth, Kloss first played professionally in the Pittsburgh area in the 1960s, and played with Pat Martino in 1965; later that year he made his first recordings at age 16 for Prestige Records. He continued to release on Prestige Records and Muse Records through the late 1970s, playing with Don Patterson, Jaki Byard, Richard Davis, Alan Dawson, Cedar Walton, Jimmy Owens, Kenny Barron, Jack DeJohnette, Booker Ervin, Chick Corea, Barry Miles (musician), Terry Silverlight, Richie Cole, and Gil Goldstein.