Karamelo Santo is a Latin rock band from Mendoza, Argentina. Formed in 1993, they released their first album, La Kulebra (The snake) in 1995. Since then, they have released nine more albums. The single "Nunca" is probably their best-known song. It was used on the soundtrack for the movie Mariposas en la Oscuridad.

The band was the first to introduce cumbia style rock. The band's song "Los Botones" was originally written for the first album in 1988. The band plays a mix of rock, ska, jazz, salsa, folk, rap, reggae, funk and cumbia. The lineup has changed over the years, but the main members have always been the co-founders: singer Guillermo Ogalde Gluzman (known as Goy) and Pedro Rosafa. The band has collaborated with several famous musicians, such as Manu Chao, Fermin Muguruza, Sergent Garcia, Ska-P and David Byrne.