Trey Anastasio (born Ernest Joseph Anastasio III; September 30, 1964) is an American guitarist, composer, and vocalist noted for his work with the rock band Phish, and his solo career, including the Trey Anastasio Band and the orchestral "Evenings with Trey Anastasio" performed with the New York Philharmonic, the Los Angeles Philharmonic, the Atlanta Symphony Orchestra, the Baltimore Symphony, the Pittsburgh Symphony, and the Colorado Symphony.

Anastasio was a 2013 best score Tony award nominee for the Broadway musical Hands on a Hardbody. He received the 2013 Dramatist Guild Frederick Loewe award for Dramatic Composition.