Wolfgang Muthspiel (born 2 March 1965 in Judenburg, Styria) is an Austrian jazz guitarist and composer. He is the brother of the trombonist and pianist Christian Muthspiel.

He started playing the violin at six and began study of the guitar as a teenager. After studying classical and jazz guitar in Graz, he completed his studies at the New England Conservatory and the Berklee College of Music. His high reputation, even in young years, made him the replacement of Pat Metheny in Gary Burton's band.