The Ghetto Brothers were a gang (or club) and music group founded in New York City's South Bronx in the late 1960s. The gang eventually spread to much of the Northeastern United States. Like the Young Lords, they were involved in Puerto Rican nationalism, including, in the case of the Ghetto Brothers, an association with the then-new Puerto Rican Socialist Party.

The name Ghetto Brothers was chosen by Hui Cambrelen one of the original founders along with Ray delaVega and Benji Melendez. Benjamin Melendez, who left the organization in 1976, was also known as a guitarist. He led a band, also known as the Ghetto Brothers, which included his late brother Victor Melendez on bass. They released one album Ghetto Brothers - Power-Fuerza in 1971, which had only informal, local distribution. It has since been re-released on CD.