The Isley Brothers (/ˈaɪzliː/) are an American musical group originally from Cincinnati, Ohio, originally a vocal trio consisting of brothers O'Kelly Isley, Jr., Rudolph Isley and Ronald Isley. The group has been cited as having enjoyed one of the "longest, most influential, and most diverse careers in the pantheon of popular music".

Alongside a fourth brother, Vernon, the group originally performed gospel music until Vernon's death a couple years after its original formation. After moving to the New York City area in the late 1950s, the group had modest chart successes during their early years, first coming to prominence in 1959 with their fourth single, "Shout", written by the three brothers. Initially a modest charted single, the song eventually sold over a million copies. Afterwards the group recorded modestly successful works for a variety of labels, including the top 20 single, "Twist & Shout" and the Motown single, "This Old Heart of Mine (Is Weak for You)" before recording and issuing the Grammy Award-winning hit, "It's Your Thing" on their own label, T-Neck Records.